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GIAPREZA® (angiotensin II) homepage
GIAPREZA® (angiotensin II) homepage
Ordering Info

Ready. Set. Reach Target Map. Fast.

Ready. Set. Reach Target Map. Fast.

Rapidly stabilize MAP in a median of 5 minutes.

For septic or other distributive shock, act fast with GIAPREZA—the first and only vasopressor designed to regulate RAAS in your patients.1

Explore Giapreza

MAP=mean arterial pressure;
RAAS=renin-angiotensin-aldosterone system.


A catecholamine‑sparing agent
may help
save lives2-4

Learn more


Regulate a
system that
other vasopressors miss5,6

See how it works


A landmark trial
for distributive shock7

In the key findings of the Phase 3 study evaluating 321 patients with distributive shock who remained hypotensive despite fluid and vasopressor therapy, GIAPREZA8:

  • Achieved and sustained target MAP fast
  • Reduced doses of other vasopressors
See trial data


Well-tolerated compared to
 standard of care and placebo8

Learn more

Connect with a GIAPREZA sales
representative for information and support.


  1. National Center for Biotechnology Information. PubChem Compound Summary for CID 172198, angiotensin II. Accessed January 22, 2024.
  2. Martin C, Medam S, Antonini F, et al. Norepinephrine: not too much, too long. Shock. 2015;44(4):305-9. doi: 10.1097/SHK.0000000000000426
  3. Bellomo R, Forni LG, Busse LW, et al. Renin and Survival in Patients Given Angiotensin II for Catecholamine‑Resistant Vasodilatory Shock. A Clinical Trial. Am J Respir Crit Care Med. 2020;202(9):1253-1261. doi: 10.1164/rccm.201911-2172OC
  4. Buckley MS, Barletta JF, Smithburger PL, et al. Catecholamine Vasopressor Support Sparing Strategies in Vasodilatory Shock. Pharmacotherapy. 2019;39(3):382-398. doi: 10.1002/phar.2199
  5. Paravati S, Rosani A, Warrington SJ | Physiology, Catecholamines | StatPearls. Published 2022. Accessed January 22, 2024.
  6. Demiselle J, Fage N, Radermacher P, et al. Vasopressin and its analogues in shock states: a review. Ann. Intensive Care. 2020;10(1):9. doi: 10.1186/s13613-020-0628-2
  7. Andrews L, Benken J, Benedetti E, et al. Effects of angiotensin II in the management of perioperative hypotension in kidney transplant recipients. Clin Transplant. 2022;36(9):e14754. doi: 10.1111/ctr.14754
  8. Khanna A, English SW, Wang XS, et al. Angiotensin II for the Treatment of Vasodilatory Shock. N Engl J Med. 2017;377(5):419-430. doi: 10.1056/NEJMoa1704154

Important Safety Information


GIAPREZA® (angiotensin II) increases blood pressure in adults with septic or other distributive shock.



Warnings and Precautions

The safety of GIAPREZA was evaluated in 321 adults with septic or other distributive shock in a randomized, double-blind, placebo-controlled study, ATHOS-3. There was a higher incidence of arterial and venous thrombotic and thromboembolic events in patients who received GIAPREZA compared to placebo-treated patients in the ATHOS-3 study (13% vs. 5%). The major imbalance was in deep venous thromboses. Use concurrent venous thromboembolism (VTE) prophylaxis.

Adverse Reactions

The most common adverse reactions reported in greater than 10% of GIAPREZA-treated patients were thromboembolic events. Adverse reactions occurring in ≥4% of patients treated with GIAPREZA and ≥1.5% more often than placebo‑treated patients in the ATHOS-3 study were thromboembolic events (including deep vein thrombosis), thrombocytopenia, tachycardia, fungal infection, delirium, acidosis, hyperglycemia, and peripheral ischemia.

Drug Interactions

Angiotensin converting enzyme (ACE) inhibitors may increase response to GIAPREZA. Angiotensin II receptor blockers (ARBs) may reduce response to GIAPREZA.

You are encouraged to report negative side effects of prescription drugs to the FDA.
To report SUSPECTED ADVERSE REACTIONS, please contact:

La Jolla Pharmaceutical Company


U.S. Food and Drug Administration


Before administering, please see the Full Prescribing Information for GIAPREZA.

  • Prescribing Information
  • Ordering Info
  • MedWatch
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GIAPREZA® is marketed by Innoviva Specialty Therapeutics, Inc. in partnership with La Jolla Pharmaceutical Company.

© 2024 Innoviva Specialty Therapeutics™. All rights reserved. PM-GIA-00067-US | 04/24